Friday, 24 May 2013

CF Superhero Supplements: Glutathione (GSH)

Ok so Glutathione what is it and why is it good for CF??...

Glutathione is the most powerful antioxidant in the body. It is made inside most cells, not the outside! It is produce by our cells to protect them from free radicals and plays a major roll in maintaining oxidation and anti-oxidation. 
Our bodies are constantly reacting to oxygen when we breath our cells react and produce energy. The product of this process is free radicals. Free radicals, the product of everyday pollutants, attack healthy cells, this cause oxidative damage to cells, genes, DNA, membranes, tissue etc. This is the case for all chronic illnesses and the cause of degeneration. ALL tissue damage and degeneration of disease is linked to glutathione deficiency!!! CF FACT: Studies have confirmed lungs tissue is effected adversely by oxidative stress.

Antioxidants protect our cells from free radical damage! We get these naturally through eating healthy fresh foods. Hence why Juicing is such a powerful help to our health. A few great supplements/antioxidant's that support our health are: Vitamin C, Vitamin E, Beta-carotene (in carrot juice and chlorella), Selenium, Lutein, Lycopene, Coenzyme Q10, Alpha-lipoic acid, Flavonoids. Note: that Vit C, Vit E and Selenium have all been proven to be directly beneficial to CF and that Glutathione is involved the  utilization of ALL these antioxidants in our body!

Whats the big deal about Glutathione???
It's a triple threat!!! A million times more powerful an antioxidant than Vitamin C, Glutathione protects our DNA from free radicals, boosts the immune system and detoxifies the liver big time. Glutathione also has potent antiviral properties. When cellular and blood glutathione levels are significantly increased, the replication of most pathogens are slowed down or stopped.

Dr Oz Talks about Glutathione 

The CF Connection

Studies have shown CF patients to be very deficient in Glutathione and here are some of the reasons I chose to supplement with it:

#1 It's an antioxidant (protection from degeneration)

#2. It's a Mucolytic (dissolves thick mucus)

#3. regulator of inflammation (Chronic problem with CF silently cause our cells damage)

#4. Immune booster (reduce lung exacerbation's. Fight disease)

#5. Repair Cells (repair damaged tissue)

#6. Digestive Health (commonly use to help IBS and any bowel issues)

#7. Aids liver health by destroying environmental poisons (drug build up, trans fats etc.)

#8. Elevate stress and anxiety (common with any chronic illness)

#9. Anti fungal

#10. Anti Viral

#11. Anti Cataracts (important on Kalydeco)

#12. Anti Kidney stones

#13. Anti osteoporosis

#14. Anti Allergenic 

#15. Natural pain reliever 

#16.  Anti Fatigue 

Practically how does it effect CF health?

Studies into Glutathione (GSH) have confirmed that "the expression of the CFTR is associated with enhanced Gluathione (GSH) ), effux from airway epithelial cells, implicating a role for CFTR in the control of oxidative stress in the airways."The EMBO Journal Vol. 22 No. 9 pp. 1981±1989, 2003. Which basically means, respiration & tissues damage is improved and prevented. Here's a visual for you to understand the significance of Epithelial cells in CF the airways:

A side on view of how a CF airway eventually looks after CFTR dysfunction, oxidative stress, inflammation and chronic infection = Bronchiectasis

This is what nebulized GSH directly works on to improves and prevent, by dissolving mucus, reducing inflammation and helping the CFTR to function better. 

Taking an oral Glutathione will also enhance this process from the inside out. Fact is ALL the cells in a chronically ill body would benefit from glutathione. General inflammation, digestion , liver, absorption, pain, diabetes, bone health, dental health.... EVERYTHING! 

My personal experience
Along with the other supplements I have been writing about, I started taking GSH regulatory over 8 weeks ago. I started with just the inhaled GSH which made my airways feel mush better, less inflammation and the mucus was effected. A lot of coughing initially  but ultimately thinner and lighter in colour. It did hit a baseline and so I started oral liposomal glutathione (GSH) as well. This enhanced and gave an additional overall improvement. I feel energetic, deeper breaths, increased FEV and I feel like I am getting stronger all the time and the positive effect has sustained this whole time. I still remain off antibiotic over 8 weeks!! 
If feels like I've cracked the code of my CF!

This blog has been a challenge for me. It so complex, difficult and unreal to try to convey in a short space the potential of amazing antioxidant, whether your on Klaydeco or not! I could write on and on.. I am sure I will have missed something important!! (I may edit it in later) Please take the time to read some studies I have linked below, nothing I take has so many CF specific studies to prove how this will directly contribute to CF health.
My lungs and general health feel the strongest I have since starting Kalydeco a year ago... in fact since I was a child!!!! 

On fire!

Links Glutathione (GSH) Supplements that I found to be Quality

 Reduced L-Glutathione™ Plus capsules for nebulizing

ReadiSorb Liposomal Glutathione

LivOn Laboratories, Lypo-Spheric GSH

Always shop around online for sales!!!!

Please note: I make my own Liposomal Supplements now, but these retail versions were what I started with. If you do decided it helps your health I can say making Liposomal supplements is very easy and makes taking long term high doses affordable. The link below this is a recipe on 'how to make Liposomal Vitamin C'. I follow these guidelines for making both Liposomal Vitamin C and Liposomal Glutathione.

Further reading

New insights into the pathogenesis of cystic fibrosis: pivotal role of glutathione system dysfunction and implications for therapy:

Glutathione:A Radical Treatment for Cystic Fibrosis Lung Disease? 

The Role of GSH in Cystic Fibrosis: 

Dr. Clark T. Bishop, M.D.: Protocol for Augmentation of GSH Levels in Cystic Fibrosis Patients, and Related Information:

 Glutathione Metabolism and Its Implications for Health: 

New Insights Into the Pathogenesis of Cystic Fibrosis:

Effects of Antioxidant Vitamins C and E on Oxidised LDL–Induced Adaptive Increases in Cystine Transport and Glutathione:

 The Journal of Cystic Fibrosis: 'Improvement in Clinical Markers in CF patients using a reduced Glutathione regimen: An uncontrolled & observational study':

Published in Nature: CFTR directly mediates neuleotide-regulated glutathione flux

 Springer Link: 'Glutathione exhibits antibacterial activity and increase tetacycline efficacy against Pseudomonas aeruginosa' 

Journal of Applied Physiology: 'Systemic deficiency of glutathione in Cystic Fibrosis'

Brigham Young University Article: 'New insight into Pathogenesis of Cystic Fibrosis; Pivotal role of Glutathione':
The importance of glutathione in human disease:

Potential for antioxidant therapy of cystic fibrosis:

Pseudomonas aeruginosa pyocyanin directly oxidizes glutathione and
decreases its levels in airway epithelial cells:


  1. Hi Faye, Thanks for the great article. I agree that glutathione is definitely the key to 'cracking the code' for cystic fibrosis! Supplementing my glutathione levels (with Cellgevity) is my main strategy to stay well - my lung function and overall health are better now than they were ten years ago! I don't take any antibiotics anymore. :)
    Cellgevity contains the glutathione precursors the body needs, in a form that is readily absorbed, and also contains curcumin, selenium and all the other good things we need in CF.
    Best wishes, Lucy (from

    1. I cannot agree with you more Lucy!! Really has amazed me HOW much difference it has made. Really happy I heard of it & even more so that I tried it!!
      Take care, Faye :)

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  3. Hi. I might be starting kalydeco soon! I have been on cellgevity for years and love it. Do you take kalydeco and cellgevity together? Has kalydeco worked for you? Thanks